TEAM LEADER : Anne Eichmann
Mail : anne.eichmann@inserm.fr
PHONE :+33 1 53 98 79 54
Localisation : Lab 360, 3rd floor
DOCTORAL SCHOOL :
Research in the Eichmann group concerns vascular system development and contribution to human pathologies. Endothelial cells (ECs) that constitute the vascular system proliferate and differentiate at the same rate as the organism grows, to ensure oxygen and nutriment supply of tissues and cells. In adults, vascular development becomes quiescent and EC proliferation occurs only in certain physiological situations (wound healing, physical exercise, pregnancy) and pathologies, including diabetes, ageing-associated macular degeneration, tissue ischemia (heart, brain, legs) and malignant tumors.
The long-term goal of the laboratory is to understand the cellular and molecular mechanisms controlling vascular patterning. We aim to identify key molecular events underlying angiogenesis, lymphangiogenesis and arteriogenesis and to establish the principles governing development of the vertebrate vascular system. Vessel networks are vulnerable to diseases, and abnormal vascular development in cardiovascular disease, cancer and diabetes is the major cause of morbidity and mortality in the developed world. We expect that understanding mechanisms controlling developmental vessel patterning will lead to novel strategies to prevent these diseases.
Current research uses genetically modified mice and quail combined with multiphoton live imaging and signaling studies in cultured cells to address three novel topics: