Logo

SMALL ANIMAL IMAGING

Objective

The small animal imaging facility of the PARCC is a part of the Paris Descartes imaging facility : Plateforme Imageries du Vivant.

PIV is a network created in 2005. Its objective is to give access to small animal imaging techniques to research teams affiliated either to Paris Descartes University, or to other groups from academic institutions or private industry.


This facility gathers imaging teams on several sites of the Paris Descartes University. The localization of the imaging systems corresponds to specific local skills for each modality:

Paris-Cardiovascular research Center (PARCC, Inserm UMR970, Georges Pompidou European Hospital) houses the small animal magnetic resonance imaging (MRI), positron emission tomography (PET) and optical imaging
Institut Cochin houses the high resolution ultrasound facility for small animals.
Cordeliers Research Center houses a conventional ultrasound
Saints Pères Center houses the electronic paramagnetic resonance imaging (RPEi) facility and two research teams expert in image and signal processing
The Pharmacy Faculty houses the luminescence and fluorescence imaging
The Dental Faculty houses the micro CT imaging
Sainte-Anne Hospital houses the clinical MRI facility


The Paris Descartes “Plateforme Imageries du Vivant” is a GIS IBISA platform, member of the FLI network. It operates in close cooperation with three Boards. The Board of Directors gives the strategic orientations of the platform. The Executive Board, composed of the scientists in charge of each imaging site and user representatives, ensures the application of the orientations given by the Board of Directors. The Scientific Council provides advices and evaluations of the scientific activities of the platform.

Equipment

MRI
A Bruker Biospec 4.7T MRI with a 40cm bore allowing to image from mice to rabbits.
High resolution cryogenic probe allowing improved signal-to-noise ratio
Complete monitoring and anesthesia systems

 

MICRO PET
A Mediso NanoScan micro PET / CT allowing to image rabbits to mice.
High resolution (0,7 mm)
Complete monitoring and anesthesia systems

 

OPTICAL IMAGING
A BioSpace planar Photon Imager camera allowing in vivo luminescence and fluorescence imaging in animal and cells.
A confocal fibered Cellvizio Lab system, an in situ dynamic fluorescence microscopy facility, to acquire movies of small animal in vivo at the cellular level

Facility Organisation

Services offered
Advice to the users to define the modalities and imaging protocols best fitting their scientific project, elaboration of the imaging.
MRI, PET/CT, Optical acquisitions, measures and analysis, and housing of their small animals during the project.

Research Engineer: Gwennhael Autret and Thomas Viel
Image processing and advanced analysis technologies and methodologies advice to researchers.
Research Engineer: Daniel Balvay

Special expertise
Thanks to the close connection with team 2 headed by Olivier Clément, the platform has developed multiparametric imaging protocols for:
Functional imaging of tumors (perfusion, permeability, diffusion, oxygenation, metabolism)
Functional imaging of the placenta in rats or mice
Cellular imaging with iron oxide particles using the high resolution cryoprobe

Contacts – (health status, pricing, etc.) please contact:
Gwennhael Autret – Research Engineer MRI: gwennhael.autret@inserm.fr (01 53 98 80 46)
Thomas Viel – Research Engineer PET/CT & optic: thomas.viel@inserm.fr (01 53 98 79 73)
Daniel Balvay – Research Engineer imaging treatment: daniel.balvay@inserm.fr (01 53 98 80 31)

Funding