TEAM LEADERS : Nabila Bouatia-Naji and Xavier Jeunemaitre
Mail : nabila.bouatia-naji@inserm.fr
PHONE :+33 1 53 98 80 23
Localisation : Labs 177, offices 159, 160 1st Floor
DOCTORAL SCHOOL : BioSPC – Development, genetics, reproduction, neurobiology and aging (DGRNV)
Team 3 investigates several human cardiovascular diseases including inherited arterial hypertension, tubulopathies and rare vascular diseases (mainly Fibromuscular Dysplasia and
vascular Elhers-Danlos Syndrome).
We aim at identifying causative genes and underpinning the molecular mechanisms using clinical, animal and cellular approaches.
We apply three complementary strategies:
1. High throughput genetic and genomic approaches on families and large cohorts of patients recruited at the National Reference Centre for Rare Vascular Diseases
at HEGP hospital;
2. Characterization of cellular and transgenic mouse models to analyse the WNK pathway and the KLHL3-CUL3 ubiquitin ligase complex and investigate their role in vascular tone, ion transport and blood pressure regulation;
3. Clinical and translational research using cohorts of patients and newly developed experimental models to identify circulating and genetic biomarkers and test new therapeutic strategies.
